Low catalytic activity of the Cu(II)-binding motif (Xxx-Zzz-His; ATCUN) in reactive oxygen species production and inhibition by the Cu(I)-chelator BCS.
Santoro A, Walke G, Vileno B, Kulkarni P P, Raibauta L, Faller P.
Chemical Communications, 2018.
This work was performed in collaboration with Peter Faller’s group.
The catalytic redox activity of Cu(II) bound to the motif NH2–Xxx-Zzz-His (ATCUN) with ascorbate and H2O2/O2 is very low and can be stopped via Cu(I)-chelation. This impacts its application as an artificial Cu–enzyme to degrade biomolecules via production of reactive oxygen species in a Cu(I)-chelator rich environment like the cytosol.